CORDIS Project
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This project investigates how transcription factors and epigenetic modifiers influence the differentiation of mouse embryonic stem cells into gastruloids. It aims to develop methods for simultaneously analyzing transcription and epigenetic states in single cells, enhancing our understanding of cell fate determination d…
During development, a cell's fate will become increasingly restricted, facilitated by the combined activity of transcription factors and epigenetic modifiers.
Single-cell RNA sequencing has greatly improved our appreciation of the transcriptional dynamics underlying lineage specification.
However, we still do not fully comprehend how epigenetic modifiers guide this highly dynamic process, as methods that enable us to accurately concatenate a cell's past and present epigenetic state with its curr…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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