CORDIS Project
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This project aims to explore the epigenetic regulation of genes involved in sperm differentiation to understand male infertility. Using mouse models, it seeks to identify how epigenetic changes may contribute to unexplained infertility cases in humans.
Human infertility affects ~15% of couples, each partner being equally likely to be affected.
Sperm differentiation anomalies such as sperm absence, malformation or reduced motility, are commonly found in infertile men but their cause remains unknown in ~75% of the cases.
In mammals, sperm differentiation requires a high proportion of genes located on the sex chromosomes and a tight epigenetic control of their expression.
Alterations of the epigenetic marks associated with these spermiogenic gene…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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