CORDIS Project
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This project investigates how changes in DNA methylation and histone modifications lead to the silencing of apoptotic genes in hepatocellular carcinoma. By understanding these mechanisms, the research aims to develop targeted cancer therapies that selectively activate apoptosis in cancer cells, potentially improving tr…
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and thus constitutes a major health problem involving more than half a million new cases every year.
During its promotion stage, HCC has been associated with defective apoptosis and increased cell proliferation.
Only recently, gene expression has been shown to be regulated by epigenetics (reversible heritable changes in gene regulation that occur without a change in DNA sequence) involving changes in DNA methylation pattern…
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