CORDIS Project
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This project explores the functional roles of epigenetic changes in cancer, particularly leukemia. It aims to develop tools for targeted editing of the epigenome to better understand how these alterations drive cancer development and progression.
Epigenetic alterations can be detected in all cancers and in essentially every patient.
Despite their prevalence, the concrete functional roles of these alterations are not well understood, for two reasons:
First, cancer samples tend to carry many correlated epigenetic alterations, making it difficult to statistically distinguish relevant driver events from those that co-occur for other reasons.
Second, we lack tools for targeted epigenome editing that could be used to validate biological functi…
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