CORDIS Project
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This project studies epigenetic inheritance and chromatin organization using the model organism C. elegans. It aims to understand how specific histone modifications influence gene regulation and stress responses, contributing to the broader knowledge of genome stability.
Epigenetic inheritance is the transmission of information, generally in the form of DNA methylation or post-translational modifications on histones that regulate the availability of underlying genetic information for transcription. RNA itself feeds back to contribute to histone modification.
Sequence accessibility is both a matter of folding the chromatin fibre to alter access to recognition motifs, and the local concentration of factors needed for efficient transcriptional initiation, elongatio…
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