CORDIS Project
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This project investigates how epigenetic mechanisms, particularly nucleosomes, maintain gene expression and chromosome organization across cell divisions. It aims to uncover the inheritance of epigenetic marks and their stability through innovative experimental strategies.
Epigenetic mechanisms heritably maintain gene expression states and chromosome organization across cell division.
These include chromatin-based factors that are propagated independent of local DNA sequence elements, and are critical for normal development and prevent reprogramming, e.g. during induction of pluripotency.
We focus on the role of nucleosomes, the histone-DNA complexes that make up chromatin.
While prominently implicated in epigenetic memory, how histones and their local modificatio…
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