CORDIS Project
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This project aims to investigate a novel therapy for epilepsy using microRNA modulation. By studying the effects of a specific microRNA antagonist on human brain tissue, it seeks to provide insights into potential new treatments for epilepsy.
The overall research aim of EpimiRTherapy is to elucidate the mechanism of a novel disease-modifying therapy for epilepsy at single cell resolution in the human brain.
MicroRNAs are short non-coding RNAs which regulate protein levels in the brain.
Certain microRNAs are strongly associated with epilepsy and their knockdown, using antisense molecules called ‘antagomirs’, has anti-seizure effects in rodents.
Antagomir targeting microRNA-134 (ant-134) is a particularly promising disease-modifying tr…
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