CORDIS Project
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This project focuses on understanding how DNA damage affects chromatin organization in mammalian cells. By using advanced imaging techniques, it aims to explore the dynamics of histone proteins and higher-order chromatin structures in response to DNA lesions.
Protection of genome integrity is crucial for maintaining cell identity and viability.
However, the organisation of DNA with histone proteins into chromatin in eukaryotic cell nuclei poses structural constraints to the detection and repair of DNA lesions.
Dynamic and tightly controlled changes in chromatin organisation are thus critical for an efficient response to DNA damage, while at the same time preserving chromatin integrity.
Yet, the underlying regulatory mechanisms are still poorly charac…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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