CORDIS Project
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This research explores the interactions between the gut microbiota and the immune system to understand inflammatory bowel diseases. It focuses on how genetic mutations affect gut health and the role of programmed cell death in triggering intestinal inflammation.
The cross talk between the host and the microbiota is believed to be the major determinant of health and disease in the gastrointestinal tract.
Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the intestine with unclear aetiology.
Deregulation of the cross talk between the intestinal microbiota and the host immune system is considered a main factor contributing to IBD.
Genomic studies revealed associations of NOD2 and of genes regulating autophagy and ER stress with an in…
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