CORDIS Project
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This project investigates the mechanisms that regulate the development and effector properties of invariant Natural Killer T cells. It focuses on the balance between specific transcription factors and their inhibitors during cell differentiation, aiming to enhance understanding of immune responses.
Invariant Natural Killer T (iNKT) cells are a heterogeneous T lymphocyte population that possess innate-like characteristics and contribute to host defense against pathogens.
Due to their powerful effector properties, iNKT cells are targeted for immunotherapeutic and vaccination strategies.
Their effector programs are acquired during thymic development, prior to microbial exposure, and are polarized into three distinct populations, similar to CD4 Th1, Th2 and Th17 lineages.
Specification and sub…
BIOMEDICALSCIENCES RESEARCH CENTER ALEXANDER FLEMING
EREVNITIKO KENTRO VIOIATRIKON EPISTIMON ALEXANDROS FLEMINGK
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