CORDIS Project
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This project investigates how epigenetic changes, particularly in DNA methylation and histone modifications, influence the expression of non-coding RNAs in cancer. The goal is to enhance understanding of tumor biology and improve diagnostic and therapeutic strategies.
In recent years, my laboratory, as well as others, have established the observation that epigenetic disruption, particularly in the DNA methylation and histone modification patterns, contributes to the initiation and progression of human tumors (Esteller, Nat Rev Genet 2007;
Esteller, N Engl J Med 2008;
Esteller, Nat Rev Biotech, In Press, 2010).
Even more recently, it has been recognized that microRNAs, small non-coding RNAs that are thought to regulate gene expression by sequence-specific base…
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
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