CORDIS Project
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This project investigates how the physical properties of the trophectoderm, the first epithelium in mammalian embryos, influence its development and patterning. Using advanced techniques like microfluidics and optical tweezers, it aims to understand the mechanics behind epithelial stretching and lumen formation.
Epithelia operate major biological functions throughout the human body.
Forming de novo during preimplantation development, the trophectoderm (TE) is our first epithelium.
The TE mediates the formation of the first mammalian lumen, which involves considerable physical challenges.
Indeed, pressurized fluid, pumped through the TE, fractures intercellular contacts before cells squeeze this fluid into a single lumen.
We recently found that cell adhesion and cell contractility determine the position…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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