CORDIS Project
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EpiPluriRetro investigates how transposable elements, particularly LINE-1 retrotransposons, are regulated in pluripotent cells. The project aims to understand their role in genetic diversity and the potential impact of their activity on human genome evolution and disease emergence.
Almost half of the human genome is made of Transposable Elements (TEs), whose ongoing activity continually impacts our genome.
However, little is known about how the host regulates TEs and their genomic and epigenomic impacts.
EpiPluriRetro will advance research in a new groundbreaking concept: that TEs are active in our pluripotent genome, and that epigenetic regulation is employed therein to regulate TE activity. LINE-1 retrotransposons comprise approximately 20% of the mammalian genome, and L…
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