CORDIS Project
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This project focuses on developing novel cancer therapeutics by creating hybrid molecules that inhibit multiple enzymes involved in epigenetic modifications. By targeting both Lysine-specific histone demethylase 1A and either Protein arginine N-methyltransferase 5 or Histone deacetylases, the project aims to enhance tr…
Cancer is a multifactorial disorder involving different genetic and epigenetic alterations.
Since epigenetic modifications are brought about by multiple enzymes working synergistically, multitargeting compounds may be particularly effective to acutely interfere with aberrant processes.
The simultaneous inhibition of two or more enzymes by a single molecule provides improved therapeutic efficacy compared to single-target inhibitors, along with reduced insurgence of drug resistance.Through this pr…
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Italy, Pavia
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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