CORDIS Project
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EpiPur aims to explore the role of the P2X7 receptor in epilepsy, focusing on its potential as a therapeutic target. The project combines advanced biosensing techniques and transgenic models to investigate the receptor's involvement in neuroinflammation and seizure mechanisms.
Current epilepsy therapies, based on mediating excitation or inhibition have no impact on disease progression and are ineffective in over 30% of patients, demonstrating the urgent need for therapies with different mechanisms of action.
An exciting concept is that increased hyperexcitability states and network changes are caused and maintained by a sustained glial activation.The ATP-gated P2X7 receptor (P2X7R), a gatekeeper of inflammation, has recently emerged as a promising target for epilepsy,…
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