CORDIS Project
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This project investigates the chromatin remodeling process during sperm development, particularly the exchange of histones for protamines. By using a novel in vitro system, it aims to understand how these changes affect epigenetic information transmission to offspring.
During spermatogenesis, germ cells go through important chromatin remodelling steps, the most striking being the replacement of histones by protamines, which promotes the compaction of the paternal genome in the sperm .
However, a proportion of nucleosomes, ~1% in mice and ~15% in humans, are retained following protamine incorporation.
It is thought that those remaining histones might play a role in the development process after fertilization possibly by transmitting epigenetic information to th…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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