CORDIS Project
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EpiScope aims to map the 3D architecture of chromatin at the single-cell level to understand cellular identity and function. By employing innovative microscopy techniques, it will explore the relationship between chromatin structure and gene expression, shedding light on mechanisms of cellular differentiation and memor…
In Eukaryotes, cellular identity and tissue-specific functions are linked to the epigenetic landscape and the multi-scale architecture of the genome.
The packing of DNA into nucleosomes at the ~100 bp scale and the organization of whole chromosomes into functional territories within the nucleus are well documented.
At an intermediate scale, chromosomes are organised in megabase to sub-megabase structures called Topologically Associating Domains (TADs).
Critically, TADs are highly correlated to p…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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