CORDIS Project
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This project seeks to develop a cost-effective method for mapping the epigenetic status of DNA at single-molecule resolution. Utilizing CRISPR technology and magnetic tweezers, it aims to explore the impact of epigenetic modifications on DNA behavior.
Next-generation DNA sequencing technologies are at the core of modern molecular biology and are rapidly entering the technological arsenal for personalized medicine.
The recent explosion of sequencing technologies has provided researchers with various solutions to fit their sequencing needs, with a large spectrum of costs and limitations.
However, most sequencing methods use enzymatic duplication of DNA to generate a strong enough sequencing signal.
Therefore, chemical modifications potentially…
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