CORDIS Project
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This project investigates how environmental factors like diet and stress influence the RNA profiles in mammalian sperm, which may affect the traits of their offspring. Using advanced RNA sequencing technology, it aims to understand the dynamics of sperm RNA and its modifications during sperm development.
Mammalian sperm RNA is increasingly recognized as an additional source of paternal hereditary information beyond DNA.
Environmental inputs, such as diet and stress, can reshape the sperm RNA signature and induce offspring phenotypes that relate to paternal environmental stressors.
However, how, when and to what extent sperm RNA populations change, and what is the role that RNA modifications and other post-transcriptional regulatory layers play in shaping sperm RNA dynamics, remains poorly unders…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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