CORDIS Project
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This project investigates the transcriptional regulation of TFEB, a key factor in lysosomal function and cellular stress response. By exploring how TFEB expression varies across different cell types and conditions, it seeks to enhance our understanding of its role in maintaining cellular homeostasis and its implication…
The discovery that lysosomal biogenesis is subjected to a global transcriptional control and that the transcription factor TFEB is the primary driving force for the coordinated expression of lysosomal genes has empowered intense investigations on the molecular mechanisms regulating cellular homeostasis.
Modulation of TFEB expression and activity is therefore crucial in cellular adaptation to a wide variety of internal stresses and environmental fluctuations.
While many studies have been focused…
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