CORDIS Project
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This project focuses on identifying genes that control cellular senescence in prostate epithelial cells. It aims to uncover novel tumor suppressor genes that could play a role in prostate cancer development.
Cellular senescence was originally described as the cell cycle arrest that accompanies the exhaustion of replicative potential in cultured primary mammalian cells.
Whereas ‘replicative’ senescence is triggered by telomere erosion, other stimuli such as activated oncogenes, oxidative stress, DNA damage and sub-optimal culture conditions can also induce a senescent phenotype called ‘premature’ senescence or ‘stasis’.
Senescence acts as a potent antitumor mechanism.
Malignant transformation occurs…
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