CORDIS Project
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This project investigates how DNA methylation patterns are established during mammalian development and their impact on cell differentiation. By using engineered mouse cells and advanced imaging techniques, it aims to uncover the dynamics of DNA modifications and gene expression at a single-cell level.
Over the past decade, epigenetic phenomena have taken centre stage in our understanding of gene regulation, cellular differentiation and human disease. DNA methylation is a prevalent epigenetic modification in mammals, which is brought about by enzymatic transfer of methyl groups from the S-adenosylmethionine (SAM) cofactor by three known DNA methyltransferases (DNMTs).
The most dramatic epigenomic reprogramming in mammalian development occurs after fertilization, whereby a global loss of DNA me…
VILNIAUS UNIVERSITETAS
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