CORDIS Project
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This project aims to improve adoptive T cell therapy for cancer and autoimmune diseases by addressing challenges related to T cell senescence and functional plasticity. It will explore epigenetic modifications to enhance T cell survival and functionality.
Adoptive T cell therapy is a promising approach in various clinical settings, from target-specific immune reconstitution fighting cancer and chronic infections to combating undesired immune reactivity during auto-immunity and after organ
transplantation.However, its clinical application is currently hampered by: 1) the acquisition of senescence during the required in vitro expansion phase of T cells which limits their survival and fitness after infusion into the patient,
and 2) the functional pl…
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