CORDIS Project
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This project investigates the genetic and epigenetic factors influencing obesity by studying specific genes that regulate chromatin states. It aims to understand how these factors contribute to non-Mendelian variations in obesity and identify potential therapeutic targets.
Substantial evidence indicates that even when genetically matched, we are not created equal.
The mechanisms underlying such non-Mendelian phenotype variation are sufficient to elicit complex disease but remain unknown.
In this context, the regulators of chromatin state have the ability to establish cellular memory, which is encoding specific silenced gene expression states through mitosis and is involved in control phenotypic variation.Interestingly, two chromatin ‘stabilizing’ genes (Trim28 / D…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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