CORDIS Project
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This project investigates the mechanisms by which specific receptors drive the remodeling of the endoplasmic reticulum through a process called ER-phagy. By examining how receptor clustering and ubiquitination regulate this process, the research aims to enhance understanding of cellular responses to stress and their im…
The endoplasmic reticulum (ER) is the most extensive endomembrane system of the cell that undergoes continuous remodelling and adaptation to fulfil required functions in synthesis and transport of cellular components. A major driver of ER remodelling is ER-phagy, a selective autophagy pathway that targets excess or damaged portions of ER for degradation.
By linking the ER membrane to the autophagic machinery, ER-phagy receptors play central roles in this process.
However, beyond the identities o…
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
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