CORDIS Project
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This project investigates how dietary factors and genetic alterations can influence lifespan and health in model organisms. By studying the effects of dietary restriction and nutrient balance, it aims to uncover mechanisms that could lead to interventions for age-related diseases in humans.
The diseases of older age are a major challenge to human societies.
Despite the complexity of ageing, both reduced food intake (dietary restriction) and simple genetic alterations can greatly increase lifespan and provide broad-spectrum protection against diseases of ageing in laboratory animals.
Furthermore, there is strong evolutionary conservation of mechanisms.
For instance the nutrient-sensing insulin/IGF and TOR signalling network modulates lifespan in yeast, invertebrates and rodents.
The…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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