CORDIS Project
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This project explores the role of the endoplasmic reticulum in regulating immune responses and inflammation. It aims to identify specific signaling pathways that emerge from the endoplasmic reticulum and their impact on innate immunity.
The endoplasmic reticulum (ER) serves many general functions, including the facilitation of protein folding and the transport of synthesized proteins, but it also has an important and more specialized role in sensing cellular stress. ER-stress identifies a group of signals that induce a transcriptional program enabling cells to survive protein overload and injury in the ER.
This highly coordinated response involves three parallel signaling branches localized at the ER, namely IRE1, ATF6 and PERK…
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