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EscapeX investigates the biological factors contributing to sex differences in cardiovascular diseases by studying genes that escape X chromosome inactivation. Using a mouse model, the project aims to identify protective mechanisms and develop potential sex-specific therapies for cardiovascular health.
Cardiovascular diseases (CVD) occur and progress differently in men and women, and the risk dramatically increases with age.
Hormone differences have been suggested to account for the sex difference by observing that younger women are regularly protected from CVD until post-menopause.
However, hormone replacement therapies failed to provide cardioprotection, suggesting that other biological factors contribute to sex disparities in CVD development.
Other likely contributors to sex bias are genes…
TECHNISCHE UNIVERSITAET MUENCHEN
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