CORDIS Project
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This project aims to develop a new framework for studying how cancer cells transition to chemoresistance. By combining spatial proteomics with a novel high-dimensional phenotyping approach, it seeks to monitor changes in living cells and identify potential therapeutic targets in breast cancer.
This proposal aims to address a critical knowledge gap in understanding phenotypic transitions in the context of chemotherapy resistance.
Phenotypic transitions encompass various mechanisms that modify cellular phenotypes over time, including differentiation and metabolic reprogramming, among others.
As some cellular phenotypes are transient and chemoresistant cells constitute a rare subpopulation, studying these important phenomena is challenging even with modern, high dimensional phenotyping m…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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