CORDIS Project
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This project focuses on understanding how the extracellular matrix influences bladder cancer progression. It aims to create a tailored microenvironment for cancer cells to study their interactions, potentially leading to new therapeutic targets.
Over the last 30 years, researchers have shown that tumor cells not only need to accumulate oncogenic genetic alterations, but also rely on permissive cues from a surrounding extracellular matrix (ECM) for malignant progression.
However, reconstructing the tumor niche in vitro has not been easy due to the complexity of its intertwined physico- biochemical properties and the limitation of the available biomimetic scaffolds.
Furthermore, preclinical studies have mainly focused on druggable targets…
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