CORDIS Project
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This project evaluates the safety and effectiveness of oral anticoagulants in preventing thrombotic disorders by incorporating genetic testing into treatment protocols. It aims to determine if knowing a patient's genetic profile can improve dosing accuracy and reduce the risk of complications.
The effectiveness of treatment with oral anticoagulants in the prevention of thrombotic disorders is well established, but these drugs are potentially dangerous because of their narrow therapeutic index.
In Europe three coumarins are used: warfarin, acenocoumarol, and phenprocoumon.
Genetic factors that have been recently demonstrated to change the pharmacokinetics and pharmacodynamics of coumarins are the presence of polymorphisms in the genes encoding for CYP2C9 and VKOR (vitamin K epoxide re…
UNIVERSITEIT UTRECHT
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Leiden University Medical Center
Netherlands, Leiden
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Netherlands, Rotterdam
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Germany, Ulm
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
United Kingdom, Newcastle Upon Tyne
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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