CORDIS Project
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This project investigates how chronic hepatitis B virus infection leads to dysfunctional immune cells and seeks to develop methods to restore their antiviral functions. It combines mouse models and patient studies to explore immune pathways and potential therapeutic strategies.
This proposal aims to investigate the development of dysfunctional adaptive immune cells during chronic hepatitis B virus (HBV) infection and to develop new strategies to reprogram them into functional cells with potent antiviral activity.
Our hypothesis, based on extensive preliminary data, is that HBV induces a unique type of adaptive immune cell dysfunction that differs from that observed in other viral infections or cancer.
To investigate this, we will use unique mouse models of HBV pathogen…
UNIVERSITA VITA-SALUTE SAN RAFFAELE
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