CORDIS Project
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This project studies the role of extracellular vesicles in communication between vascular cells, focusing on long non-coding RNAs and their impact on vascular health. It aims to uncover mechanisms that could lead to new therapies for cardiovascular diseases.
Background:
The concept of extracellular vesicles (EVs) has drastically changed from the initial non-functional debris to the current of key mediators of paracrine signalling.
The cargoes of EVs comprise all kinds of macromolecules, and recent evidence has demonstrated the presence of long non-coding RNAs (lncRNAs) in such vesicles.
These RNA molecules have numerous potential regulatory functions and results obtained so far guide us to presume a determinant role in vascular cell differentiation,…
THE UNIVERSITY OF EDINBURGH
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