CORDIS Project
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This project focuses on the EVI1 oncogene, which is linked to several aggressive cancers. By exploring its regulatory mechanisms and potential therapeutic targets, the research aims to develop strategies for treating EVI1-driven malignancies.
Deregulation of the EVI1 oncogene is a key transforming event in the development of many malignancies, most prominently very high-risk acute myeloid leukemia (AML), ovarian, colon, breast, non-small cell lung cancer, and soft-tissue sarcoma.
For decades, both EVI1 function and the mechanism underlying its deregulation have been poorly understood.
The consequent lack of a targeted therapy against EVI1 establishes a pressing medical need.
In a recent study investigating a distinct category of EVI1…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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