CORDIS Project
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This project aims to enhance the production of nonribosomal peptides, which have various bioactive properties, by developing a new system for evolving the enzymes that synthesize them. It focuses on improving the efficiency and diversity of potential drug candidates.
Nonribosomal peptides are a highly important class of natural products and display a broad spectrum of bioactivity, ranging from antimicrobial and immunosuppressant to anticancer.
They are synthesized by non-ribosomal peptide synthetases (NRPSs), a diverse group of large multifunctional enzymes that operate as molecular assembly lines.
They consist of modules that are responsible for coupling, processing and modification of an extending chain of amino acid monomers, heterocyclic rings and N-meth…
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