CORDIS Project
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This project investigates how enhancer regions in DNA communicate with gene promoters, focusing on their evolutionary dynamics across different mammalian species. By analyzing high-resolution data, it aims to uncover the genetic factors influencing long-range gene regulation and develop predictive models using machine…
Gene regulation is fundamental to biological diversity, driving differences between cell types within an organism and contributing to variation between species. DNA regions known as enhancers play a critical role in this process.
Enhancers can be located millions of base pairs away from the genes they regulate, interacting with the promoters of these genes through 3D contacts within the nucleus.
How enhancers find their target genes remains largely elusive.
Evolution offers a unique “natural per…
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