CORDIS Project
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This project aims to understand cancer development as an evolutionary process by studying genetic and epigenetic changes in tumor cells. It combines theoretical models with experimental techniques to explore how these changes contribute to cancer heterogeneity.
Our working hypothesis is that tumorigenesis is an evolutionary process that fundamentally couples few major driving events (point mutations, rearrangements) with a complex flux of minor aberrations, many of which are epigenetic.
We believe that these minor events are critical factors in the emergence of the cancer phenotype, and that understanding them is essential to the characterization of the disease.
In particular, we hypothesize that a quantitative and principled evolutionary model for car…
WEIZMANN INSTITUTE OF SCIENCE
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