CORDIS Project
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This project investigates the genomic evolution of protozoan parasites, focusing on how they adapt by losing or gaining genes. By comparing these changes in parasites and their free-living relatives, the research aims to uncover evolutionary patterns and identify protein families that may influence disease processes.
Protozoan parasites from diverse evolutionary lineages including Trypanosoma and Leishmania, Giardia, Entamoeba, Plasmodium and the microsporidia have a major impact on human health, especially in developing countries and among immunocompromised individuals.
During their evolution as parasites these organisms can both lose pathways if they can steal host metabolites and gain genes that may help them to manipulate their hosts.
It is this balance of genome reduction and genome expansion, and the p…
UNIVERSITY OF NEWCASTLE UPON TYNE
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