CORDIS Project
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This project investigates the role of Transposable Elements, specifically LINE-1 retrotransposons, in the human genome. It aims to understand their impact on genomic variability, neuronal development, and cancer by studying new somatic insertions and their consequences.
The present structure of the human genome is largely a result of the activity of Transposable Elements (TEs) or jumping genes.
Indeed, they have constantly provided genomic variability over evolution, resulting in the generation of new genes and new regulatory circuits among others, and they are still doing it now, mainly leaded by the activity of few classes of TEs as LINE-1 retrotransposons.LINE-1s are the only autonomous active TEs currently mobile in the human genome, and its activity has be…
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