CORDIS Project
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This research explores the evolution of gene regulatory elements in sea urchins, utilizing single-cell sequencing technologies to map tissue-specific gene expression. The project aims to understand how mutations in these elements contribute to developmental changes and the emergence of new cell types.
Cell types in development arise from precise patterns of gene expression driven by differential usage of DNA regulatory elements.
Mutations affecting these elements, or proteins binding them, are major contributors to disease and underlie the evolution of new morphologies.
To better understand these elements and how they evolve, I introduce a set of single-cell RNA and ATAC-Seq sequencing technologies that:
A) Identify tissue-specific regulatory elements and expression profiles by interrogating…
HUMBOLDT-UNIVERSITAET ZU BERLIN
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