CORDIS Project
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This project develops a new model for understanding protein evolution, focusing on the role of epistasis, or the interaction of mutations. By linking protein fitness to their physico-chemical properties, the model aims to enhance predictions of protein behavior, which could lead to advancements in medical diagnostics a…
Proteins evolve to highly diverged sequence, function and structure.
The dynamics of protein evolution is fundamental for understanding how natural protein evolve, and also for creating new proteins in the laboratory for medical and industrial use. “Epistasis”, which is the interaction between the effects of mutations, is often observed in nature and is the central to understand the dynamics of evolution, because it shapes the passages in the evolution.
However, epistasis has been considered to…
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