CORDIS Project
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This project investigates the dynamics of antibiotic resistance evolution by developing a novel experimental assay that simulates spatial drug concentration gradients. The goal is to understand how these gradients affect bacterial evolution and resistance, with broader implications for cancer treatment.
Given the looming antibiotic resistance crisis, it is imperative to understand the fundamental determinants of resistance evolution dynamics.
When antibiotics are administered to a patient, imperfect drug penetration leads to a highly inhomogeneous concentration profile.
In contrast, evolution experiments to study resistance are commonly performed in homogeneous liquid environments.
Recently, there has been a surge of theoretical studies suggesting that spatial drug concentration gradients drast…
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