CORDIS Project

EVPRO - Development of Extracellular Vesicles loaded hydrogel coatings with immunomodulatory activity for Promoted Regenerative Osseointegration of revision endoprosthesis

EVPRO·814495·H2020

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Funding data

Programme: Horizon 2020
Participants: 4
Start - End: 01/01/2019 — 30/11/2023
Status: CLOSED

Summary

EVPRO addresses inflammation issues in revision endoprostheses by utilizing extracellular vesicles derived from human stem cells. This project aims to enhance the healing process by integrating these vesicles into a biodegradable hydrogel, which will be applied directly to the implant site to promote regeneration.

Objective

Revision endoprosthesis are mostly associated with post-surgical physical symptoms that can lead to long-term confinement to bed and in severe cases to implant rejection.

Severe inflammatory reactions in the endoprosthesis shaft can occur due to a previous long-term prosthesis.

Medically managing the inflammation process is challenging as it is difficult to introduce drugs to the site of inflammation after implantation of the revision endoprosthesis. EVPRO overcomes this problem by using human m…

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Coordinator

Fraunhofer

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV

Country: Germany, Munchen
Organization type: Research institute
Activity type: Research Organisations
SME: No

Network and participants(4 participants)

Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.

UKESSEN
Germany, Essen
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
participant
LONZA COLOGNE GMBH
Germany, Koln
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
thirdparty
LONZA NETHERLANDS BV
Netherlands, Maastricht
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
participant
DCU
Ireland, Dublin
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
participant

4 participants shown of 13

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CORDIS call / funding scheme

Programme: H2020
Call: H2020-NMBP-TR-IND-2018-2020
Sub call: H2020-NMBP-TR-IND-2018
Funding scheme: RIA - Research and Innovation action
Domain note: This block describes the CORDIS project call context. Live open opportunities are managed in the Funding & Tenders domain.

Fields of Science (EuroSciVoc)

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Engineering and technologyMaterials engineeringCoating and films
Medical and health sciencesBasic medicinePharmacology and pharmacyDrug discovery
Medical and health sciencesMedical biotechnologyImplants

Topic

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NMBP-22-2018

Keywords

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mesenchymal-derived extracellular vesicles Revision endoprosthesis hydrogel Inflammation TiO2-surface coating