CORDIS Project
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This project investigates the biology of extraembryonic endoderm stem cells to understand their maintenance and differentiation mechanisms. By exploring the roles of receptor tyrosine kinases and Wnt signaling, the research aims to enhance stem cell manipulation for applications in regenerative medicine.
The goals of regenerative medicine require a deep understanding of cell lineage and differentiation, developmental potential and fate.
Stem cells representing each of the three first cell lineages of the mammalian blastocyst embryo, TS (trophectoderm), XEN (extraembryonic endoderm, exEn) and ES (epiblast) can be isolated, maintained and differentiated and provide tremendous tools for cell-based therapies.In this proposal, I will dissect the molecular mechanisms of maintenance and differentiation…
INSTITUT PASTEUR
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