CORDIS Project
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This project investigates the role of extracellular nucleosomes and chromatin in exacerbating brain injury after a stroke. By using advanced imaging techniques in animal models, it aims to clarify the molecular mechanisms involved, potentially leading to improved treatment strategies for stroke patients.
Stroke is associated with the death of brain tissue and is a significant cause of mortality and disability among survivors.
Tissue necrosis, in addition to the active release of chromatin by activated neutrophils, a process known as NETosis, results in the release of extracellular nucleosomes, DNA, and histones (ExNDH).
Such processes serve to exacerbate the initial tissue injury and promote a pro-inflammatory state, thereby amplifying the original injury.
The evidence supporting this hypothesis…
UNIVERSITETET I OSLO
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