CORDIS Project
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This project investigates how the nuclear RNA exosome and its adaptor complexes manage RNA turnover in human cells. By employing a novel methodology, it aims to track interactions between RNA-binding proteins and newly synthesized RNA, enhancing our understanding of RNA quality control mechanisms.
The human genome is ubiquitously transcribed into far more RNA than is immediately needed.
Consequently, RNA turnover becomes critical for keeping our cells healthy.
The nuclear RNA exosome degrades the majority of short-lived RNA species within cell nuclei and is hereby the gatekeeper of an enormous RNA synthesis output.
To perform this essential task, the exosome employs so-called ‘adaptor complexes’ (ExoACs), which contribute to target specificity.
While the trimeric nuclear exosome targeting…
AARHUS UNIVERSITET
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