CORDIS Project
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The project investigates the process of degrading misfolded proteins in the Endoplasmic Reticulum, known as Endoplasmic Reticulum-associated degradation. It aims to identify specific differences in how mammalian cells handle various protein substrates, which could inform therapies for diseases like cystic fibrosis and…
The misfolded, unfolded or unassembled proteins in the Endoplasmic Reticulum (ER) are degraded by the “Protein Quality Control Mechanism” named as ER-associated degradation (ERAD).
In addition to its safeguard role, ERAD can regulate physiological processes that occur in the ER, for example degradation of HMG–CoA reductase, the key enzyme of cholesterol synthesis. ERAD is a multistep process, which starts with substrate (unwanted protein) selection followed by ubiquitination, retrotranslocation,…
EGE UNIVERSITY
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