CORDIS Project
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This project explores the role of senescent cells in cancer treatment, aiming to enhance the effectiveness of therapies like chemotherapy and immunotherapy. By understanding the interactions between these cells and immune therapies, it seeks to improve outcomes for solid tumors.
Senescence is a two-component process comprised of a stable cell cycle arrest and a secretory program named the senescence associated secretory phenotype (SASP), altering the surrounding microenvironment.
The program serves as a tumor suppressive mechanism inhibiting the propagation of damaged cells, but the accumulation of senescent cells has been connected to multiple age-associated diseases including cancer.
Consequently, senescence induction in tumors is not considered a desired therapeutic…
EBERHARD KARLS UNIVERSITAET TUEBINGEN
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