CORDIS Project
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This project investigates the role of neurexins and neuroligins in synapse formation and their impact on the excitation/inhibition balance in the brain. It aims to understand how genetic mutations linked to Autism Spectrum Disorders affect synaptic functions and morphology using a novel mouse model.
Controlling the precise balance between excitation and inhibition (E/I balance) is critical for information processing in the brain.
This equilibrium is regulated at the level of individual synapses, which can be either excitatory or inhibitory depending of the type of neurotransmitter released.
It is well established that cell adhesion molecules such as neurexins (NRXs) and neuroligins (NLs) play important roles in synapse formation and specification.
In humans, several genetic mutations in NLs…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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France, Bordeaux
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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