CORDIS Project
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This project investigates rare genetic variants affecting the immune system to uncover mechanisms behind inflammation and blood cell development. It aims to enhance understanding of myeloid cell function and develop innovative gene and cell-based therapies for conditions like severe congenital neutropenia.
Genomic system biology approaches offer new aspects to understand the basis of diseases and to develop new therapeutic strategies.
Here, we propose to study rare human variants of the immune system to provide novel explanations of mechanisms governing inflammation and leukemogenesis.
Following a full circle of translational research, our group has previously defined several novel clinical entities and elucidated their molecular defects (Nat Med 2007, NEJM 2009).
Further studies have highlighted…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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